Evolutionary adaptation of plant annexins has diversified their molecular structures, interactions and functional roles

摘要: Contents   Summary 695 I. Introduction 695 II. Structural analyses 696 III. Membrane-related functions 702 IV. Enzyme-related functions 703 V. Functional insights from proteome and transcriptome analyses 704 VI. Future perspectives 706   Acknowledgements 708   References 708 Summary Annexins are an homologous, structurally related superfamily of proteins known to associate with membrane lipid cytoskeletal components. Their involvement in organization, vesicle trafficking signaling is fundamental cellular processes such as growth, differentiation, secretion repair. Annexins exist some prokaryotes all eukaryotic phyla within which plant annexins represent a monophyletic clade homologs descended green algae. Genomic, proteomic transcriptomic approaches have provided data on the diversity, localization expression patterns different annexins. The availability 35 complete genomes has enabled systematic comparative analysis determine phylogenetic relationships, characterize structures observe functional specificity between individual subfamilies. Short amino termini selective erosion canonical type 2 calcium coordinating sites domains 3 typical convergent evolution alternate motifs ‘KGD’, redox-sensitive Cys hydrophobic Trp/Phe residues argues for their relevance contribution mechanistic diversity This review examines recent findings advances annexin research special focus structural molecular interactions potential integrated functions broader context physiological responses.