Studies on the diurnal variations of 17-hydroxyprogesterone in saliva by enzyme immunoassay in patients with congenital adrenal hyperplasia.

摘要: The diurnal rhythm of 17-hydroxyprogesterone concentration in the saliva was determined 11 patients with congenital adrenal hyperplasia ranging age from 9 to 20 years. A total 21 tests were performed using a 17-OHP-enzyme immunoassay. investigations carried out during normal school or working days. done 16 times optimal therapeutic control and 5 undertreatment. concentrations 17-OHP morning significantly lower after therapy interval night 8 hours than more 10 hours. In poor substitution all values days higher control. are appropriate for evaluation With regular hours' intervals limit between pathological may be about 500 pmol/l saliva.