Trajectories of Fasting Blood Glucose in Autologous Hematopoietic Cell Transplantation.

摘要: BACKGROUND Patients who receive autologous hematopoietic cell transplantation (HCT) for the treatment of hematologic malignancies are at risk serious adverse outcomes including infections and death. Hyperglycemia following HCT is associated with increased these outcomes. However, limited information available on demographic clinical characteristics that contribute to changes in blood glucose levels HCT. OBJECTIVE The objective this study was determine trajectories fasting (FBG) as well predicted interindividual differences FBG trajectories. METHODS A sample adult patients were scheduled (n = 53) enrolled study. preexisting diabetes excluded. Demographic abstracted from electronic medical records. Morning laboratory tests (ie, absolute neutrophil counts) obtained. Data analyzed using hierarchical linear modeling day (day 0) through 14 days post-HCT. RESULTS Among 8 evaluated, pre-HCT variability both initial FBG. Body mass index only CONCLUSIONS large amount suggests control warrants ongoing assessments preemptive tailoring. IMPLICATIONS FOR PRACTICE Fasting monitoring warranted. Additional research larger samples warranted identify additional modifiable nonmodifiable levels.