Genomic circuits and the integrative biology of cardiac diseases.

摘要: Human cardiac disease is the result of complex interactions between genetic susceptibility and environmental stress. The challenge to identify modifiers disease, design new therapeutic strategies interrupt underlying pathways. availability genomic databases for many species uncovering networks conserved cardiac-specific genes within given physiological A classification human diseases can be envisaged based on disruption integrated circuits that control heart morphogenesis, myocyte survival, biomechanical stress responses, contractility electrical conduction.