In vivo quantification of choline compounds in the breast with 1H MR spectroscopy.

摘要: This work describes a methodology for quantifying levels of total choline-containing compounds (tCho) in the breast using vivo (1)H MR spectroscopy (MRS) at high field (4 Tesla). Water is used as an internal reference compound to account partial volume adipose tissue. Peak amplitudes are estimated by fitting one peak time over narrow frequency band allow measurement small metabolite resonances spectra with large lipid peaks. quantitative method significantly improves previously reported analysis methods accounting variable sensitivity MRS measurements. Using this technique, we detected and quantified tCho 214 500 spectra. were found be higher malignancies than benign abnormalities normal tissues, which suggests that technique could diagnose suspicious lesions monitor response cancer treatments.