An overview of pancreatic exocrine secretion.

摘要: Abstract 1. Genes for all proteins have encoded in their DNA sequences, information that specifies where these will localize within the cell. Nascent translation products of transcripts genes, possess a specific NH 2 -terminal signal sequence, are able to translocate into specialized membranous conducting system called endoplasmic reticulum (ER), or can be incorporated directly target organelle (i.e. mitochondrion). polypeptides lacking this sequence remain cytosol. 2. Once segregation ER has occurred each protein appears migrate at characteristic rate connecting organelle; Golgi Complex. Here, enzymatic modifications determines with which eventually become associated. 3. In secretory tissues such as exocrine pancreas, many different directed structures zymogen granules. These granules maintained “ready-to-release” state by steroid hormones. absence estrogens and glucocorticoids disappear. 4. Physiologically, secretion from pancreas is brought about parasympathetic nerve stimulation, gut hormone cholecystokinin (CCK). Interaction acetylcholine CCK receptors on pancreatic acinar cells initiates process exocytosis; is, fusion granule membrane plasma resulting extracellular release contents granule.