Flow dynamics using high-frequency jet ventilation in a model of bronchopleural fistula

摘要: Abstract Background Positive pressure ventilation in patients with a bronchopleural fistula (BPF) is associated variable, unpredictable gas leaks that can impair exchange. The optimum settings for high-frequency jet this scenario are unclear. We investigated flow dynamics BPFs of 2 and 10 mm, at various positions different ventilator bench-top model. Methods A or mm length was created proximal, middle, distal sites standard artificial ‘test' lungs cadaveric porcine lungs. effects alterations frequency, applied pressure, on entrained, expired, leak volumes were determined using gauge differential sensors. Results Entrained, delivered, affected markedly by settings, particularly frequency: much greater frequencies −1 . leak/expired volume ratio varied between 0% 92%. Leak entrained increased progressively more proximally situated fistulae, whereas the measured expired decreased. approximately half across all frequencies. All driving pressure. injection time depending BPF position accepted compromise volumes. Entrained contributed up to 50% total tidal volume. Conclusions These data suggest will be minimized maintained during >200 min lower pressures, but confirmatory clinical studies required. Values displayed unreliable.