Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.
作者： Seira Narishige , Mari Kuwahara , Ayako Shinozaki , Satoshi Okada , Yuko Ikeda
DOI: 10.1111/BPH.12890
关键词:
摘要: Background and Purpose Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist main suprachiasmatic nucleus (SCN) clocks peripheral clocks. Although caffeine lengthens circadian modifies phase changes in SCN-operated rhythms, effects on phase, period amplitude organ are not known. In addition, role cAMP/Ca2+ signalling rhythm has been fully elucidated.
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