Xanthines as Adenosine Receptor Antagonists
作者： Christa E. Müller , Kenneth A. Jacobson
DOI: 10.1007/978-3-642-13443-2_6
关键词:
摘要: The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR) antagonists described in literature. They exhibit micromolar affinities are non-selective. A large number of derivatives analogues subsequently synthesized evaluated as AR antagonists. Very potent have thus been developed with selectivity for each four subtypes.
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