Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators.

摘要: Context: In men, GH secretion is stimulated by estradiol derived locally from aromatization of testosterone. Recently, we showed that local estrogen also plays a major role in the central regulation women. Tamoxifen and raloxifene are selective receptor modulators (SERMs), drugs block action but exert estrogen-like effects liver, inhibiting hepatic IGF-I production. The relative impact SERMs on GH-IGF-I axis men women has not been investigated. Objective: aim study was to determine whether there gender difference axis. Design: We conducted comparative, randomized, open-label, crossover tamoxifen raloxifene. Patients Intervention: Ten healthy postmenopausal ten were randomized 2-wk sequential treatment with (10 20 mg/d) (60 120 washout 2 wk between treatments. Main Outcome Measures: r...