Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice.
作者： Mélanie Bourque , Marc Morissette , Thérèse Di Paolo
DOI: 10.1016/J.NEUROBIOLAGING.2014.03.017
关键词:
摘要: Raloxifene, used in the clinic, is reported to protect brain dopaminergic neurons mice. Raloxifene was shown mediate an effect through G protein-coupled estrogen receptor 1 (GPER1). We investigated if raloxifene neuroprotective 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated male mice mediated GPER1 by using its antagonist G15. Striatal concentrations of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid dopamine ratio as well transporter and vesicular monoamine 2 showed that neuroprotection blocked Protection accompanied activation striatal Akt signaling (but not ERK1/2 signaling) increased Bcl-2 brain-derived neurotrophic factor levels; these effects were abolished coadministration with The levels 17β-estradiol. MPTP had decreased plasma testosterone, dihydrotestosterone, 3β-diol this prevented raloxifene-treated Our results suggest acted activation, increase levels, protection androgens.
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