In vivo metabolism of 3H-testosterone in adult male rats: effects of estrogen administration.
作者： D.K.H. Lee , C.E. Bird , A.F. Clark
DOI: 10.1016/0039-128X(75)90011-2
关键词: Adult male 、 Endocrinology 、 Internal medicine 、 Chemistry 、 Kidney 、 Estradiol valerate 、 Testosterone 、 Metabolism 、 Estrogen 、 Vesicle 、 Prostate
摘要: Abstract The metabolism of testosterone (T) was studied in normal adult male rats using a constant infusion trace amounts the 3 H-steroid into tail vein for h order to attain state equilibrium. Samples plasma, liver, kidney, prostate, seminal vesicles and muscle were analysed H-testosterone, H-5α-dihydrotestosterone (5αDHT) H-5α-androstanediol (Adiol). When compared H-T level plasma there high levels kidney H-5αDHT prostate vesicles. Intraperitoneal estradiol valerate administration (100 μg/ day) 4 days decreased increased estrogen T metabolic clearance rate from 17.5 1/24 h/ 100 g body wt 22.6 h/100 wt.
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