Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat
作者： K. Fuxe , N. Kurosawa , A. Cintra , Å. Hallström , M. Goiny
DOI: 10.1007/BF02259134
关键词:
摘要: The present study examines the possibility that lesions induced by intrastriatal injections of endothelin-1 (ET-1, 0.43 nmol/0.5 microliter) are ischemic in nature due to a vasoconstriction cerebral microvessels. In time course and dose-response experiments with ET-1 comparisons ET-3, volume has been determined based mainly on disappearance striatal nerve cells, using computer assisted morphometrical analysis. blood flow neostriatum close site injection was acutely Laser-Doppler flowmetry. acute metabolic effects were also studied superfusate levels lactate, pyruvate, dopamine its metabolites DOPAC (3,4-dihydroxyphenylacetic acid) homovanillic acid (HVA) an microdialysis probe. Dose related observed (0.043-0.43 nmol) peak lesion after 24-48 h possible existence penumbra area. ET-3 showed reduced potency produce compared ET-1. prevented coinjection dihydralazine, vasodilator drug. Acutely (0.43 produced prolonged reduction down 40% control values temporary increases lactate DA efflux, latter change being very marked. Also significant HVA observed. These neurochemical changes all treatment dihydralazine.(ABSTRACT TRUNCATED AT 250 WORDS)
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