Hypokalaemia in alcoholic patients

作者: MOSES ELISAF , EVANGELOS LIBEROPOULOS , ELENI BAIRAKTARI , KOSTAS SIAMOPOULOS

DOI: 10.1080/09595230220119282A

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摘要: Hypokalaemia is commonly found among the electrolyte abnormalities observed in chronic alcoholics. However, underlying mechanisms of decreased potassium levels are not well known. We undertook present study to analyse possible pathogenetic hypokalaemia a large group alcoholic patients (n = 127) admitted our hospital for causes related alcohol abuse. Serum were significantly lower compared control population (3.8 + 1.1 mmol/l vs. 4.6 0.9 mmol/l). In 12 these inappropriate kaliuresis was due mainly coexistent hypomagnesaemia. Two remaining four had history diarrhoea, while other two withdrawal syndrome with considerable respiratory alkalosis. Patients hypomagnesaemia and alkalosis more normokalaemic ones. conclude that relatively common abnormality owing various pathophysiological mechanisms. Among them, co-existent predominates.

参考文章(22)
K C Siamopoulos, E V Tsianos, M Merkouropoulos, M Elisaf, Acid-base and electrolyte abnormalities in alcoholic patients. Mineral and Electrolyte Metabolism. ,vol. 20, pp. 274- 281 ,(1994)
George Kaysen, Robert H. Noth, The Effects of Alcohol on Blood Pressure and Electrolytes Medical Clinics of North America. ,vol. 68, pp. 221- 246 ,(1984) , 10.1016/S0025-7125(16)31251-2
Gerhard Giebisch, Lawrence Berger, Robert F. Pitts, Mary Ellen Parks, Martha B. MacLeod, THE EXTRARENAL RESPONSE TO ACUTE ACID-BASE DISTURBANCES OF RESPIRATORY ORIGIN Journal of Clinical Investigation. ,vol. 34, pp. 231- 245 ,(1955) , 10.1172/JCI103076
Robert S. Brown, Extrarenal potassium homeostasis. Kidney International. ,vol. 30, pp. 116- 127 ,(1986) , 10.1038/KI.1986.160
Keith D. Wrenn, Corey M. Slovis, Gregg E. Minion, Roman Rutkowski, The syndrome of alcoholic ketoacidosis. The American Journal of Medicine. ,vol. 91, pp. 119- 128 ,(1991) , 10.1016/0002-9343(91)90003-G
M. Elisaf, K. C. Siamopoulos, Fractional excretion of potassium in normal subjects and in patients with hypokalaemia. Postgraduate Medical Journal. ,vol. 71, pp. 211- 212 ,(1995) , 10.1136/PGMJ.71.834.211
M. Elisaf, E. Rizos, K. Siamopoulos, Potassium excretion indices in the diagnostic approach to hypokalaemia. QJM: An International Journal of Medicine. ,vol. 93, pp. 318- 319 ,(2000) , 10.1093/QJMED/93.5.318
José Marco, Javier Diego, Maria L. Villanueva, Maruxa Díaz-Fierros, Isabel Valverde, José M. Segovia, Elevated Plasma Glucagon Levels in Cirrhosis of the Liver The New England Journal of Medicine. ,vol. 289, pp. 1107- 1111 ,(1973) , 10.1056/NEJM197311222892103
Sergio De Marchi, Emanuela Cecchin, Antonio Basile, Alessandra Bertotti, Renato Nardini, Ettore Bartoli, Renal tubular dysfunction in chronic alcohol abuse : effects of abstinence The New England Journal of Medicine. ,vol. 329, pp. 1927- 1934 ,(1993) , 10.1056/NEJM199312233292605
M. Elisaf, M. Merkouropoulos, E.V. Tsianos, K.C. Siamopoulos, Pathogenetic mechanisms of hypomagnesemia in alcoholic patients Journal of Trace Elements in Medicine and Biology. ,vol. 9, pp. 210- 214 ,(1995) , 10.1016/S0946-672X(11)80026-X