Metformin in chemically-induced mammary carcinogenesis in rats

摘要: In this paper the chemopreventive effect of peroral antidiabetic metformin in mammary carcinogenesis female Sprague-Dawley rats was evaluated. Mammary induced by N-methyl-N-nitrosourea (NMU) administered two intraperitoneal doses each per 50 mg/kg b.w. between 43.-55. postnatal days. Metformin drinking water (at a concentration microg/ml and 500 microg/ml) 13 days before first NMU dose until termination experiment. During experiment animals were weekly weighed palpated for presence tumors, incidence, latency, tumor frequency, volume recorded. The terminated 18 weeks after dose, basic growth parameters metabolic hormonal variables did not significantly alter although delay onset recorded higher dose. altered variables. Insulinemia decreased both comparison with intact without changes glycemia, triacylglycerols liver increased serum when compared to intacts. Higher attenuated lipoperoxidation liver.