Response to methotrexate in a patient with idiopathic eosinophilic fasciitis, morphea, IgM hypergammaglobulinemia, and renal involvement.

摘要: A 35-year-old man with idiopathic eosinophilic fasciitis (EF) and morphea developed renal disease characterized by microscopic hematuria, nephrotic range proteinuria, rapidly progressing hypertension, an association that has not previously been reported in EF. Initial clinical symptoms of EF began July 1989; peripheral eosinophilia peaked at 30% August 1990; abnormal urinalysis was first observed March 1992 subsequently a biopsy performed. Renal demonstrated focal segmental glomerulosclerosis subepithelial immune-type deposit. Partial fasciectomy course methotrexate resulted overall functional improvement his extremities. Proteinuria hematuria reduced during therapy.