Histological classification of the neoplastic changes arising in ulcerative colitis: A new proposal in Japan

摘要: Patients with total ulcerative colitis a longstanding course of the disease have high risk developing colorectal carcinoma. Colonoscopic surveillance to detect precancerous tissue and/or cancer in these patients has been carried out countries incidence colitis. Riddell's classification widely used for interpretation biopsy specimens obtained from colonoscopic surveillance. In Japan, however, there are problems accepting classification, mainly because intramucosal carcinomas diagnosed by Japanese histopathologists included category high-grade dysplasia classification. Based on results meticulous slide review seven this study, new is proposed: UC-I, inflammatory change; UC-II, indefinite; UC-IIa, probably inflammatory; UC-IIb, neoplastic; UC-III, neoplastic but not carcinomatous; and UC-IV, Intramucosal UC-IV. We consider that diagnosis carcinoma be made when grade cytological structural atypia consistent Interobserver intraobserver variability was acceptable. believe will use Japan.