Impact of mucosal inflammation on risk of colorectal neoplasia in patients with ulcerative colitis: a systematic review and meta-analysis

摘要: Background and Aims Long-standing ulcerative colitis is an established risk factor for colorectal neoplasia. A number of observational studies have suggested that evidence mucosal inflammation (endoscopic or histologic) associated with a greater neoplasia than healing. Our goal was to systematically analyze the in patients who ongoing better inform surveillance strategies. Methods We performed systematic review meta-analysis effect endoscopic and/or histologic on cohort case-control studies. Sensitivity analyses study setting case definition were performed. Results Six met inclusion criteria, incorporating outcomes 1443 patients. No used single validated measure inflammation. The pooled odds ratio 3.5 (95% confidence interval [CI], 2.6-4.8; P  Conclusion presence objective during follow-up subsequent those This should be considered guidelines intervals these