Growth factor therapy and neuronal nitric oxide synthase.

摘要: Trauma to the cavernous nerve is a known cause of erectile dysfunction, with lengthy and often incomplete recovery. Using rat models, we have previously shown that injury nerves or ligation pudendal arteries causes significant decrease neuronal nitric oxide synthase (nNOS) in dorsal penis intracavernosal tissue as well loss response neurostimulation. Intracavernous injection vascular endothelial growth factor brain-derived neurotrophic facilitates recovery nNOS function. Studies are underway elucidate molecular mechanism regeneration potential using factors enhance function patients after radical pelvic surgery.