Effects of Low‐Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model

摘要: Introduction. Low-energy shockwave therapy (LESWT) has been shown to improve erectile function in patients suffering from diabetes mellitus (DM)-associated dysfunction (ED). However, the underlying mechanism remains unknown. Aim. The aim of this study is investigate whether LESWT can ameliorate DM-associated ED a rat model and examine associated changes tissues. Methods. Newborn male rats were intraperitoneally injected with 5-ethynyl-2-deoxyuridine (EdU; 50 mg/kg) for purpose tracking endogenous mesenchymal stem cells (MSCs). Eight weeks later, eight these randomly chosen serve as normal control (N group). remaining 60 mg/kg streptozotocin (STZ) induce DM. DM (DM group), whereas another subject (SW) treatment (DM+SW Each DM+SW group received 300 shocks at energy level 0.1 mJ/mm 2 frequency 120/minute. This procedure was repeated three times week weeks. Another all 24 evaluated by intracavernous pressure (ICP) measurement. Afterward, their penile tissues examined histology. Main Outcome Measures. Erectile measured ICP. Neuronal nitric oxide synthase (nNOS)-positive nerves endothelium immunofluorescence staining. Smooth muscle MSCs phalloidin EdU staining, respectively. Results. STZ caused significant decrease number nNOS-positive endothelial smooth contents. These deficits partially but significantly reversed LESWT. (EdU-positive cells) more numerous than rats. Conclusion. promoting regeneration nerves, endothelium, penis. beneficial effects appear be mediated recruitment MSCs. Qiu X, Lin G, Xin Z, Ferretti L, Zhang H, Lue TF, C-S. Effects low-energy on tissue diabetic model. J Sex Med **;**:**-**.