Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure.

摘要: Objectives Direct application of low-energy unfocused shock waves induces angiogenesis in ischemic soft tissue. The potential effects epicardial wave therapy applied direct contact to myocardium are uncertain. Methods For induction heart failure a rodent model, left anterior descending artery ligation was performed adult Sprague–Dawley rats. After 4 weeks, reoperation with (treatment group, n=60) or without (control performed. Low-energy were the infarcted (300 impulses at 0.38 mJ/m 2 ). Additionally, healthy animals (n = 30) normal studied. Angiogenesis, ventricular function upregulation growth factors, and brain natriuretic peptide levels analyzed. Results Histologic analysis revealed significant 6 weeks group: 8.2 ± 3.7 vs control 2.9 1.9 vessels per field, P .016) 14 7.1 3.1 3.2 1.8 .011) after treatment. In treatment group improved throughout follow-up period (6 weeks: 37.4% 9% [ Conclusion improves model failure.