Bioinspired Nanonetworks for Targeted Cancer Drug Delivery

摘要: A biomimicry approach to nanonetworks is proposed here for targeted cancer drug delivery (TDD). The swarm of bioinspired nanomachines utilizes the blood distribution network and chemotaxis carry through vascular system site, recognized by a high concentration endothelial growth factor (VEGF). Our multi-scale includes processes that occur both within cells with their neighbors. bionanonetwork takes advantage several organic processes, some which already human body, such as plate-like structure similar those red more environmental contact; berry fruit architecture its internal multi-foams architecture; penetrable cells, tissue, well porous capillaries penetration; state glycocalyx ligand-receptor adhesion; changes in pH ${\rm O} _{2}$ release nanomachine communication. For appropriate evaluation, we compare our work conventional chemotherapy using mathematical model under actual experimental parameter settings. Simulation results show merits method therapy improving densities relevant cell types VEGF concentration, while following natural processes.