Mammalian target of rapamycin signaling pathway contributes to glioma progression and patients' prognosis.

摘要: Background The mammalian target of rapamycin (mTOR) pathway plays an important role in the regulation cell growth and increasing evidence suggests its dysregulation tumors. It also implements many other critical cellular functions, including protein degradation angiogenesis. To date, a correlation between mTOR human glioma patients' prognosis has not been reported. Methods address this question, we carried out immunohistochemical study upstream downstream targets phosphorylated Akt (pAkt), S6 ribosomal (pS6), p27, as well phosphatase tensin homologue (PTEN) using biopsies from 96 patients with primary glioma. Kaplan-Meier survival Cox regression analyses were performed to evaluate patients. Results Immunostaining revealed that was significantly associated Karnofsky performance scale (KPS) score World Health Organization (WHO) grade Especially, positive expression rates pAkt, cytoplasmic pS6 higher (P = 0.002, 0.001 0.002) lower KPS 0.007, 0.005, 0.008), which opposite nuclear p27 and PENT expression. Statistical analysis showed expressing PTEN, have different overall relative those these proteins. multi-factor 0.02), WHO 0.005), pAkt 0.009), PTEN 0.006), cytoplasm 0.01), 0.003) independent factors for Conclusion These results provide convincing first time correlated closely might be novel prognostic marker.