Protective Intranasal Immunization Against Influenza Virus in Infant Mice Is Dependent on IL-6.

摘要: Respiratory diseases adversely affect infants and are the focus of efforts to develop vaccinations other modalities prevent disease. The infant immune system differs from that older children adults in many ways as yet ill understood. We have used a C57BL/6 mouse model infection with laboratory- adapted strain influenza (PR8) delineate importance cytokine IL-6 innate response primary development protective immunity adult mice. Herein, we this same (14 days age) mice determine effect deficiency. Infant wild type more susceptible than infection, similar findings humans. is expressed lung early PR8 infection. While intramuscular immunization does not protect against lethal challenge, intranasal administration heat inactivated virus correlates expression lung, activation CD8 cells, an influenza-specific antibody response. In deficient mice, abrogated, protected challenge. These studies support role tissue environment immunity, further suggest may be helpful generation responses infants.