Alveolar macrophage interleukin (IL)-10 and IL-12 production in atopic asthma

作者: A. Magnan , D. van Pee , P. Bongrand , D. Vervloet

DOI: 10.1111/J.1398-9995.1998.TB03821.X

关键词:

摘要: Inflammation in asthma is characterized by a Th2 response. In many experimental systems, this response can be regulated interleukin (IL)-10 and IL-12. IL-10 deactivates T cells, IL-12 reorients the toward Th1 pattern. Alveolar macrophages (AM) secrete both of these cytokines, thus regulate T-cell behavior asthma. They enhance turning off their secretion IL-12, or tend to downregulate it producing cytokines. To elucidate that point, we assayed AM from 11 asthmatic patients four controls. Six asthmatics were treated inhaled corticosteroids. recovered bronchoalveolar lavage (BAL). isolated cultured for 24 h without stimulation presence lipopolysaccharide (LPS). p40 subunit BAL fluid culture supernatants ELISA. Spontaneous production was higher asthmatics, particularly group. The after LPS also elevated but mainly so untreated patients. levels fluids than LPS-stimulated-AM increased. These results show are at least primed asthma, suggest cells could involved resolution inflammation.

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