Molecular and Functional Diversity of Mammalian Na+/H+ Exchangers

摘要: Excess acid produced by cellular metabolism must be buffered or actively extruded in order to maintain acid-base equilibrium and proper cell function. In mammalian as well other eukaryotic cells, restoration of steady-state pH following acidification is achieved most efficiently the electroneutral exchange intracellular H+ for extracellular Na+; a process that mediated family integral membrane cation transporters commonly referred Na+/H+ antiporters exchangers (NHE). Aside from cytoplasmic homeostasis, NHEs contribute spectrum physiological processes, including volume regulation, fluid secretion, salt water absorption across epithelia (1, 2, 3, 4). Additionally, NHE activity thought influence events such adhesion, migration, proliferation, apoptosis (5,6). Abnormal activities certain are also associated with progression several disease states, essential hypertension (7,8), congenital secretory diarrhea (9), diabetes (10, 11, 12, 13), ischemia/reperfusion-induced injuries tissues heart (14), brain (15) kidney (16,17). This review intended briefly summarize recent findings regarding molecular functional heterogeneity gene family.