Inhibitors of sodium-hydrogen exchange as therapeutic agents for the treatment of heart disease

摘要: Na+-H+ exchanger (NHE) is a family of transporters critical importance to the regulation intracellular pH values, which act by removing protons in exchange for concomitant Na+ influx. There are at least eight isoforms NHE that have thus far been cloned, given designation NHE-1 NHE-8. so-called housekeeping isoform found most tissues and major cardiac cell. now very compelling evidence its activation contributes paradoxical induction cell injury NHE-1-selective inhibitors extensively demonstrated possess excellent cardioprotective properties appear be superior other strategies. Recent also suggests inhibition may conducive attenuating remodelling process after myocardial infarction, independently infarct size reduction attenuation subsequent postinfarction heart failure. As such, offer substantial promise clinical dev...