Invasive pulmonary aspergillosis after solid organ transplantation: diagnosis and treatment based on 28 years of transplantation experience.

作者: M.K. Ju , D.J. Joo , S.J. Kim , H.K. Chang , M.S. Kim

DOI: 10.1016/J.TRANSPROCEED.2008.11.006

关键词:

摘要: Invasive pulmonary aspergillosis (IPA) is a serious and lethal complication among organ transplant recipients. This report described the clinical manifestations treatment of IPA over 28-year period. From January 1979 to December 2007, 3215 patients (2954 kidney 261 liver recipients) were enrolled in study. Nine developed (7 2 recipients), yielding an incidence 0.003% (9/3215). Five (55.6%) diagnosed by transbronchial lung biopsy or autopsy, 3 (33.3%) sputum culture One patient was through observations characteristics on chest X ray. We used amphotericin B (n = 4; 44.4%), voriconazole 2; 22.2%), fluconazole 1; 11.1%) as primary antifungal agents, but could not receive agents due rapid disease progression sequential mortality. study showed high mortality rate (55.6%; 5/9). Only who received early agent thereby after prompt diagnosis recovered from IPA. survival advantage warrants careful monitoring for invasive fungal infections transplantation with immediate administration surgical intervention.

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