Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus

摘要: Systemic Lupus Erythematosus (SLE), among many other auto-immune diseases, is known to be more prevalent in females than males. This observation has served as the foundation for studies into how sex hormones may interact with immune system either drive or inhibit activation. Early using castration lupus mouse models showed potential protective effect of testosterone against development. These were later corroborated by observational patients, who upon treatment therapy, displayed decreased disease burden. However, there are numerous limitations treating (especially female) patients testosterone. Thus, identification testosterone-targeted cellular and molecular mechanisms affecting activation an attractive target future. Recent have examined effects androgens on anti-inflammatory processes. As such, immunoregulatory cell types including myeloid-derived suppressor cells (MDSCs) regulatory T B been shown susceptible manipulation hormones. Here, we review SLE lupus-like which testosterone-derivatives used skew ongoing reaction toward state. Via evaluation both clinical immunologic propose new areas research goal identifying testosterone-driven mediators suitable therapeutic targeting autoimmune diseases.