Adolescents' and Parents' Attitudes Toward Adolescent Clinical Trial Participation: Changes Over One Year.

作者: Rebecca K. Tsevat , Carmen Radecki Breitkopf , Sara E. Landers , Ariel M. de Roche , Christine Mauro

DOI: 10.1177/1556264618790889

关键词:

摘要: Little is known about how adolescents' and parents' thoughts participation in clinical trials change over time. In this study, adolescent (14-17 years)-parent dyads were asked willingness to participate a hypothetical reproductive health study. A year later, they their the study had changed. Qualitative responses coded analyzed using framework analysis. Thirty-two percent of adolescents 18% parents reported changes thoughts; reasons included general perception, clearer understanding, new knowledge or experiences, increased maturity/age adolescents, participants independent Adolescents may benefit from learning studies multiple times, investigators should account for development experiences optimize research enrollment.

参考文章(28)
Susan L. Rosenthal, John D. Caskey, Conducting research on sensitive topics with adolescents: ethical and developmental considerations. Journal of Developmental and Behavioral Pediatrics. ,vol. 26, pp. 61- 67 ,(2005)
Jenny K.R. Francis, Lily F. Hoffman, Mei-Chen Hu, Ariel M. de Roche, Marina Catallozzi, Carmen Radecki Breitkopf, Susan L. Rosenthal, Adolescents and Their Parents Differ on Descriptions of a Reproductive Health Study. Journal of Pediatric and Adolescent Gynecology. ,vol. 29, pp. 240- 245 ,(2016) , 10.1016/J.JPAG.2015.09.002
D. Wendler, E. Abdoler, L. Wiener, C. Grady, Views of Adolescents and Parents on Pediatric Research Without the Potential for Clinical Benefit Pediatrics. ,vol. 130, pp. 692- 699 ,(2012) , 10.1542/PEDS.2012-0068
Janet L. Brody, David G. Scherer, Robert D. Annett, Melody Pearson-Bish, Voluntary assent in biomedical research with adolescents: a comparison of parent and adolescent views. Ethics & Behavior. ,vol. 13, pp. 79- 95 ,(2003) , 10.1207/S15327019EB1301_10
Janet L. Brody, Robert D. Annett, David G. Scherer, Mandy L. Perryman, Keely M.W. Cofrin, Comparisons of adolescent and parent willingness to participate in minimal and above-minimal risk pediatric asthma research protocols. Journal of Adolescent Health. ,vol. 37, pp. 229- 235 ,(2005) , 10.1016/J.JADOHEALTH.2004.09.026
Sarah Flicker, Adrian Guta, Ethical Approaches to Adolescent Participation in Sexual Health Research Journal of Adolescent Health. ,vol. 42, pp. 3- 10 ,(2008) , 10.1016/J.JADOHEALTH.2007.07.017
Mary B. Short, Paul A. Succop, Ana M. Ugueto, Susan L. Rosenthal, Predictors of Using a Microbicide-Like Product among Adolescent Girls Journal of Adolescent Health. ,vol. 41, pp. 357- 362 ,(2007) , 10.1016/J.JADOHEALTH.2007.05.004
Katie D. Schenk, Barbara A. Friedland, Michelle Chau, Marie Stoner, Marlena Gehret Plagianos, Stephanie Skoler-Karpoff, Thesla Palanee, Khatija Ahmed, Mary Jane Malebo Rathlagana, Pamela Nombali Mthembu, Nomampondomise Ngcozela, Enrollment of adolescents aged 16-17 years old in microbicide trials: an evidence-based approach. Journal of Adolescent Health. ,vol. 54, pp. 654- 662 ,(2014) , 10.1016/J.JADOHEALTH.2014.01.014
Gail E Henderson, Larry R Churchill, Arlene M Davis, Michele M Easter, Christine Grady, Steven Joffe, Nancy Kass, Nancy M. P King, Charles W Lidz, Franklin G Miller, Daniel K Nelson, Jeffrey Peppercorn, Barbra Bluestone Rothschild, Pamela Sankar, Benjamin S Wilfond, Catherine R Zimmer, Clinical Trials and Medical Care: Defining the Therapeutic Misconception PLOS Medicine. ,vol. 4, pp. 1735- 1738 ,(2007) , 10.1371/JOURNAL.PMED.0040324
Vivek H. Murthy, Harlan M. Krumholz, Cary P. Gross, Participation in Cancer Clinical Trials JAMA. ,vol. 291, pp. 2720- 2726 ,(2004) , 10.1001/JAMA.291.22.2720