Regulation of matrix metalloproteinase-9 expression between gingival fibroblast cells from old and young rats.
作者： Su-Jung Kim , Yong-Koo Chung , Tae-Wook Chung , Jeong-Ran Kim , Sung-Kwon Moon
DOI: 10.1016/J.BBRC.2008.09.015
关键词:
摘要: Abstract Gingival fibroblast cells (rGF) from aged rats have an age-related decline in proliferative capacity compared with young rats. We investigated G1 phase cell cycle regulation and MMP-9 expression both rGF. protein levels activity were significantly reduced response to interleukin-1β (IL-1β) stimulation increasing vitro age. Tumor necrosis factor-α (TNF-α)-induced matrix metalloproteinase-9 (MMP-9) was also decreased rGF comparison Mutational analysis gel shift assays demonstrated that the lower is associated activities of transcription factors NF-κB AP-1. These results suggest dysregulation down-regulation may play a role gingival remodeling during aging.
osti.gov
elsevier.com
sci-hub.se 参考文章(32)
L M Golub, S Ramamurthy, M E Ryan, Matrix metalloproteinases and their inhibition in periodontal treatment. Current opinion in periodontology. ,vol. 3, pp. 85- 96 ,(1996)
Schroeder He, Page Rc, Pathogenesis of inflammatory periodontal disease. A summary of current work Laboratory Investigation. ,vol. 34, pp. 235- 249 ,(1976)
J. H. Bennett, M. J. Morgan, S. A. Whawell, P. Atkin, P. Roblin, J. Furness, P. M. Speight, Metalloproteinase expression in normal and malignant oral keratinocytes: stimulation of MMP‐2 and ‐9 by scatter factor European Journal of Oral Sciences. ,vol. 108, pp. 281- 291 ,(2000) , 10.1034/J.1600-0722.2000.108004281.X
H Sato, M Seiki, Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells Oncogene. ,vol. 8, pp. 395- 405 ,(1993)
H Sato, M Kita, M Seiki, v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. Journal of Biological Chemistry. ,vol. 268, pp. 23460- 23468 ,(1993) , 10.1016/S0021-9258(19)49485-4
Sung-Kwon Moon, Byung-Yoon Cha, Cheorl-Ho Kim, None, In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells. Archives of Biochemistry and Biophysics. ,vol. 418, pp. 39- 48 ,(2003) , 10.1016/S0003-9861(03)00402-8
Cheorl-Ho Kim, Sung-Kwon Moon, None, Epigallocatechin-3-gallate causes the p21/WAF1-mediated G1-phase arrest of cell cycle and inhibits matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells Archives of Biochemistry and Biophysics. ,vol. 435, pp. 264- 272 ,(2005) , 10.1016/J.ABB.2004.12.022
Tae‐Wook Chung, Sung‐Kwon Moon, Young‐Chae Chang, Jeong‐Heon Ko, Young‐Choon Lee, Gun Cho, Soo‐Hyun Kim, Jong‐Guk Kim, Cheorl‐Ho Kim, None, Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism The FASEB Journal. ,vol. 18, pp. 1670- 1681 ,(2004) , 10.1096/FJ.04-2126COM
U. Westerlund, T. Ingman, P.-L. Lukinmaa, T. Salo, L. Kjeldsen, N. Borregaard, L. Tjäderhane, Y.T. Konttinen, T. Sorsa, Human Neutrophil Gelatinase and Associated Lipocalin in Adult and Localized Juvenile Periodontitis Journal of Dental Research. ,vol. 75, pp. 1553- 1563 ,(1996) , 10.1177/00220345960750080601
Bong‐Seok Kang, Young‐Guk Park, Jin‐Young Cho, June‐Ki Kim, Tae‐Kyun Lee, Dong‐Wook Kim, Yeun‐Hwa Gu, Ikukatsu Suzuki, Young‐Chae Chang, Cheorl‐Ho Kim, None, Interleukin‐1 and Tumor Necrosis Factor‐α Induce Collagenolysis and Bone Resorption by Regulation of Matrix Metalloproteinase‐2 in Mouse Calvarial Bone Cells Immunopharmacology and Immunotoxicology. ,vol. 25, pp. 347- 364 ,(2003) , 10.1081/IPH-120024503