Cellular and molecular aspects of the renal effects of diuretic agents

摘要: The study of the renal sites and mechanisms action diuretics received a major boost by experiments conducted Dallas group in mid late sixties [1, 2]. Utilizing clearance techniques sharp judicious analysis free water excretion (C H 2 O ) reabsorption (T c curves, these investigators set basis for present knowledge nephron rational clinical use diuretics. Micropuncture isolated tubule proved most inferences general concepts developed from methodology to be correct [3]. Moreover, studies that aim assess (and other drugs) still depend on methods interpretation. In past two decades (70 80's) it has become possible examine more detail many cellular molecular These agents are one remarkable achievements pharmaceutical industry. They efficacious, relatively innocuous inexpensive drugs life-saving their short- (such as, acute hypercalcemia or hyponatremia [4, 5]) as well long-term utilization [6–8]. Most importantly, they interact with tissue targets reversible way permits swift modification dosage therapeutic goals. diuretic located along different segments nephron. Potency drugs—in practical terms, degree salt losses induce—depends precisely which part affect. Also, ancillary effects may exert systemic hemodynamics. Recent reviews have emphasized pharmacology [9–11]. Therefore, our purpose is discuss transport mechanisms, aspects interaction between targets.