Effect of systemic α1-adrenergic receptor blockade on central blood pressure response during exercise
作者： Jun Sugawara , R. Matthew Brothers , Peter B. Raven , Kazunobu Okazaki , Shigehiko Ogoh
DOI: 10.1007/S12576-013-0272-9
关键词:
摘要: The aortic pulse pressure (PP), which consists mainly of the incident wave and reflected wave, has emerged as an important property systemic blood vessels underlying pathophysiology cardiovascular disease. To determine role sympathetic nerve activity on PP response during dynamic exercise, we evaluated hemodynamics right-leg knee-extension (40 60 % maximal voluntary contraction) in six young adults with without α1-adrenergic receptor blockade using prazosin (1 mg/20 kg body weight). use attenuated exercise-induced increase (P < 0.05) but not radial arterial PP. amplitude waves (via augmentation index) significantly decreased exercise more prazosin. These results suggest that α1-adrenergic-mediated vasoconstrictor tone peripheral resistance is manifestly involved magnitude modulation responses.
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