Impact of Endocrine and Exocrine Insufficiency on Quality of Life After Total Pancreatectomy

摘要: Total pancreatectomy (TP) is rarely performed due to concerns for endocrine and exocrine insufficiency decreased quality of life (QoL). Renewed interest seen in recent years, but large cohort studies remain scarce. This study was designed evaluate after TP its impact on QoL. Adult patients (age ≥ 18 years) who underwent between 2008 2017 at Karolinska University Hospital with least 6 months follow-up were included. Endocrine QoL assessed using validated questionnaires (EORTC QLQ-C30, QLQ-PAN26, PAID20, DTSQs). Both pre- postoperative available a subgroup. Of 145 TP, 60 eligible whom 53 (88.3%) median 21 months (interquartile range [IQR] 13–54) Symptomatic hypoglycemia occurred 90.6% (48/53) patients, 25% (12/48) experienced ≥ 1 episodes loss consciousness. The PAID20 revealed emotional burnout seven (13.2%), whereas high satisfaction score diabetes treatment (median 28, IQR 24–32) measured according the DTSQs. Overall, 27 (50.9%) reported have steatorrhea during 2 days (IQR 0–4) past week. Overall reduced compared general population (66.7% vs. 76.4%; Δ9.7%) did not differ preoperative outcomes (n = 39, 66.7%; 41.7–83.3 66.7%, 50.0–83.3; P = 0.553) EORTC QLQ-C30. Although seems acceptable, management both insufficiencies should be further improved.