Exocrine Pancreatic Insufficiency After Pancreatectomy for Malignancy: Systematic Review and Optimal Management Recommendations

摘要: Exocrine pancreatic insufficiency (EPI) occurs when enzyme activity in the intestinal lumen is insufficient for normal digestion to occur. The true incidence and diagnosis of EPI after pancreatectomy has not been fully understood optimized. aim this study was present diagnostic criteria cancer provide a guide management optimal therapy patients with cancer. A comprehensive review literature publication dates from 2014 2019 performed. treatment algorithm then created based on current options. In total, 30 studies were included, 19 combined both pancreaticoduodenectomy (PD) distal (DP), 9 central pancreatectomy, 2 others. defined subjectively without definitive testing using any established majority 23 (76%). Preoperative calculated be 11.52%. Most assessed exocrine function at least 6 months postoperatively four extending follow-up period beyond 12 months. diagnosed 1 month (40.27%), 3 (30.94%), (36.06%), (34.69%). After PD, median prevalence postoperative 43.14%, CP, 4.85%, DP, 11.94%. frequent outcome that often misdiagnosed or under-reported by patient post-pancreatectomy. Given increasing overall survival cancer, surgeon awareness assessment critical improving patients’ quality life.