Studies of in vivo mutations in rpsL transgene in UVB-irradiated epidermis of XPA-deficient mice.
作者： Hiroaki Murai , Seiji Takeuchi , Yoshimichi Nakatsu , Minoru Ichikawa , Masafumi Yoshino
DOI: 10.1016/S0027-5107(00)00024-5
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摘要: Abstract We have established xeroderma pigmentosum group A ( XPA ) gene-knockout mice with nucleotide excision repair (NER) deficiency, which rapidly developed skin tumors when exposed to a low dose of chronic UV like XP-A patients, confirming that the NER process plays an important role in preventing UVB-induced cancer. To examine vivo mutation UVB-irradiated epidermis, we (−/−), (+/−) and (+/+) carrying Escherichia coli rpsL transgene frequencies spectra epidermal tissue can be examined conveniently. The (−/−) showed higher frequency (150 J/m 2 UVB-irradiation than mice, while, at high (900 they almost same as probably because cell death epidermis mice. However, CC→TT tandem transition, hallmark UV-induced mutation, was detected both doses UVB. This rpsL/XPA mouse system will useful for further analyzing mutagenesis carcinogenesis induced by various carcinogens.
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