Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.
作者： Hironobu Nakane , Seiichi Hirota , Philip J. Brooks , Yusaku Nakabeppu , Yoshimichi Nakatsu
DOI: 10.1016/J.DNAREP.2008.08.003
关键词:
摘要: We have reported that xeroderma pigmentosum group A (Xpa) gene-knockout mice [Xpa (-/-) mice] are deficient in nucleotide excision repair (NER) and highly sensitive to UV-induced skin carcinogenesis. Although patients show growth retardation, immature sexual development, neurological abnormalities as well a high incidence of tumors, Xpa were physiologically behaviorally normal. In the present study, we kept for 2 years under specific pathogen-free (SPF) conditions found testis diminished an age-dependent manner, degenerating seminiferous tubules no spermatozoa detected 24-month-old mice. addition, higher spontaneous tumorigenesis was observed compared (+/+) controls. provide useful model investigating aging internal tumor formation XPA patients.
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sci-hub.se 参考文章(51)
Elizabeth S. Russell, Hereditary Anemias of the Mouse: A Review for Geneticists Advances in Genetics. ,vol. 20, pp. 357- 459 ,(1979) , 10.1016/S0065-2660(08)60549-0
Wolfram Siede, Graham C. Walker, Errol C. Friedberg, DNA Repair and Mutagenesis ,(2006)
Lawrence J. Marnett, Oxyradicals and DNA damage Carcinogenesis. ,vol. 21, pp. 361- 370 ,(2000) , 10.1093/CARCIN/21.3.361
Teresa Roldán-Arjona, Barbara Sedgwick, DNA base damage induced by ionizing radiation recognized byEscherichia coli UvrABC nuclease but not Nth or Fpg proteins Molecular Carcinogenesis. ,vol. 16, pp. 188- 196 ,(1996) , 10.1002/(SICI)1098-2744(199608)16:4<188::AID-MC2>3.0.CO;2-C
Annemieke de Vries, Conny T. M. van Oostrom, Paul M. Dortant, Rudolf B. Beems, Coen F. van Kreijl, Peter J. A. Capel, Harry van Steeg, Spontaneous liver tumors and Benzo[a]pyrene-induced lymphomas in XPA-deficient mice Molecular Carcinogenesis. ,vol. 19, pp. 46- 53 ,(1997) , 10.1002/(SICI)1098-2744(199705)19:1<46::AID-MC7>3.0.CO;2-L
Kenneth H. Kraemer, Xeroderma Pigmentosum Archives of Dermatology. ,vol. 123, pp. 241- 250 ,(1987) , 10.1001/ARCHDERM.1987.01660260111026
Laura J. Niedernhofer, DNA repair is crucial for maintaining hematopoietic stem cell function. DNA Repair. ,vol. 7, pp. 523- 529 ,(2008) , 10.1016/J.DNAREP.2007.11.012
Mark Shannon, Jane E. Lamerdin, Laura Richardson, Sandra L. McCutchen-Maloney, Mona H. Hwang, Mary Ann Handel, Lisa Stubbs, Michael P. Thelen, Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis. Genomics. ,vol. 62, pp. 427- 435 ,(1999) , 10.1006/GENO.1999.6016
Hiroaki Murai, Seiji Takeuchi, Yoshimichi Nakatsu, Minoru Ichikawa, Masafumi Yoshino, Yoichi Gondo, Motoya Katsuki, Kiyoji Tanaka, Studies of in vivo mutations in rpsL transgene in UVB-irradiated epidermis of XPA-deficient mice. Mutation Research. ,vol. 450, pp. 181- 192 ,(2000) , 10.1016/S0027-5107(00)00024-5
K S Keegan, D A Holtzman, A W Plug, E R Christenson, E E Brainerd, G Flaggs, N J Bentley, E M Taylor, M S Meyn, S B Moss, A M Carr, T Ashley, M F Hoekstra, The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes & Development. ,vol. 10, pp. 2423- 2437 ,(1996) , 10.1101/GAD.10.19.2423