Hereditary Anemias of the Mouse: A Review for Geneticists

摘要: Publisher Summary This chapter discusses the formal genetics of mouse anemias and their significance for an analysis patterns mammalian gene action. It also describes normal hemopoietic development, homeostasis, hemoglobin polymorphism. Anemias are classified into five categories—(1) maturation arrest, (2) involving defects in iron utilization, (3) greatly reduced erythrocyte life-span, (4) hemoglobinopathies, (5) almost secondary to genetically induced defects. During total life a mouse, including prenatal hemopoiesis takes place four different sites. Although continues liver until birth brief time thereafter, (largely myelopoiesis) commences spleen on fetal day 15 or 16 marrow around birth. Hematologically adult mice from many inbred strains regularly produce more than one kind hemoglobin. There is widespread genetic polymorphism at both Hba locus, determining α-globin structure Hbb β-globin structure, loci involve considerable complexity.