Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
作者： Kevin Stark , Seppo Vainio , Galya Vassileva , Andrew P. McMahon
DOI: 10.1038/372679A0
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摘要: The kidney has been widely exploited as a model system for the study of tissue inductions regulating vertebrate organogenesis. Kidney development is initiated by ingrowth Wolfian duct-derived ureteric bud into presumptive mesenchyme. In response to signal from ureter, mesenchymal cells condense, aggregate pretubular clusters and undergo an epithelial conversion generating simple tubule. This then undergoes morphogenesis transformed excretory kidney, nephron. We report here that expression Wnt-4, which encodes secreted glycoprotein, correlates with, required for, tubulogenesis. Mice lacking Wnt-4 activity fail form cell aggregates; however, other aspects are unaffected. Thus, appears act autoinducer mesenchyme transition underlies nephron development.
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