Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
作者： Suzanne L. Mansour , Kirk R. Thomas , Mario R. Capecchi
DOI: 10.1038/336348A0
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摘要: … 1) to which we have added the HSV-tk gene at the 5" end. The linearized DNA was introduced into ES cells by electroporation and the cells were then subjected to different growth …
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R. Smith, G. Peters, C. Dickson, Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors. The EMBO Journal. ,vol. 7, pp. 1013- 1022 ,(1988) , 10.1002/J.1460-2075.1988.TB02908.X
D. G. Wilkinson, G. Peters, C. Dickson, A. P. McMahon, Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. The EMBO Journal. ,vol. 7, pp. 691- 695 ,(1988) , 10.1002/J.1460-2075.1988.TB02864.X
K THOMAS, High frequency targeting of genes to specific sites in the mammalian genome Cell. ,vol. 44, pp. 419- 428 ,(1986) , 10.1016/0092-8674(86)90463-0
Kirk R. Thomas, Mario R. Capecchi, Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells Cell. ,vol. 51, pp. 503- 512 ,(1987) , 10.1016/0092-8674(87)90646-5
A. Jakobovits, G. M. Shackleford, H. E. Varmus, G. R. Martin, Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 7806- 7810 ,(1986) , 10.1073/PNAS.83.20.7806
CLIVE DICKSON, GORDON PETERS, Potential oncogene product related to growth factors. Nature. ,vol. 326, pp. 833- 833 ,(1987) , 10.1038/326833A0
Allan Bradley, Martin Evans, Matthew H. Kaufman, Elizabeth Robertson, Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines Nature. ,vol. 309, pp. 255- 256 ,(1984) , 10.1038/309255A0
C. Dickson, R. Smith, S. Brookes, G. Peters, Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2 Cell. ,vol. 37, pp. 529- 536 ,(1984) , 10.1016/0092-8674(84)90383-0
Thomas Doetschman, Ronald G. Gregg, Nobuyo Maeda, Martin L. Hooper, David W. Melton, Simon Thompson, Oliver Smithies, Targetted correction of a mutant HPRT gene in mouse embryonic stem cells Nature. ,vol. 330, pp. 576- 578 ,(1987) , 10.1038/330576A0
M H St Clair, W H Miller, R L Miller, C U Lambe, P A Furman, Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U. Antimicrobial Agents and Chemotherapy. ,vol. 25, pp. 191- 194 ,(1984) , 10.1128/AAC.25.2.191