Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

摘要: Abstract The int-1 and int-2 genes were first isolated as targets for transcriptional activation by proviral insertion mutations in mammary carcinomas induced the mouse tumor virus (MMTV). Since these proto-oncogenes are not expressed at detectable levels previously tested normal tissues from adult mice, we sought to determine whether might be active during embryogenesis examining embryos cultured teratocarcinoma cells RNA encoded int-2. A single size class of is present only mid-gestation stages development (days 8 through 13) also detected testes postpuberal mice. Four species found peri-implantation particularly abundant derivatives primitive endodermal lineage, but mid- or late gestation any tested. Thus, two proto-oncogenes, activated carcinogenesis same mechanisms, normally different times places embryonic