Targetted correction of a mutant HPRT gene in mouse embryonic stem cells
作者： Thomas Doetschman , Ronald G. Gregg , Nobuyo Maeda , Martin L. Hooper , David W. Melton
DOI: 10.1038/330576A0
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摘要: Two recent developments suggest a route to predetermined alterations in mammalian germlines. These are, first, the characterization of mouse embryonic stem (ES) cells 1 that can still …
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