Fibronectin Mutations in Mice
作者： Elisabeth N. Georges , Elizabeth L. George , Helen Rayburn , Richard O. Hynes
DOI: 10.1007/978-1-4615-2830-2_3
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摘要: Fibronectiins (FNs) are a set of extracellular proteins found in the matrix and blood plasma which involved multiple functions, including cell adhesion migration during development, hemostasis thrombosis, or wound healing (see Hynes, 1990 for recent review). FNs comprise several isoforms, generated by alternative splicing single RNA transcript. Three sites have been describes: EIIIA, EIIIB, V segments (sometimes called EDA, EDB IIICS). EIIIA EIIIB can be completely included excluded, while segment partially totally included, depending on splice site used (Figure 1).
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