Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh.

作者: Jannah Tauheed , Marco Sanchez-Guerra , Jane J. Lee , Ligi Paul , Md Omar Sharif Ibne Hasan

DOI: 10.1080/15592294.2017.1312238

关键词:

摘要: ABSTRACTArsenic exposure may contribute to disease risk in humans through alterations the epigenome. Previous studies reported that arsenic is associated with changes plasma histone concentrations. Posttranslational modifications have been found differ between brain tissue of human embryos neural tube defects and controls. Our objectives were investigate relationships 3 levels, history having an infant myelomeningocele, biomarkers exposure, maternal folate deficiency. These took place Bangladesh, a country high environmental contaminated drinking water. We performed ELISA assays concentration total (H3) modification H3K27me3. The samples collected from 85 adult women as part case-control study myelomeningocele Bangladesh. significant associations %H3K27me3 l...

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