Influence of Cytokines and Growth Factors on Distinct Steroidogenic Enzymes in Vitro
作者： M. HERRMANN , J. SCHÖLMERICH , R. H. STRAUB
DOI: 10.1111/J.1749-6632.2002.TB04213.X
关键词:
摘要: Cytokines (IL-1, IL-6, IL-8, IL-11, TNF, IFN-gamma, and TGF-beta) growth factors (EGF, bFGF, aFGF, KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps steroidogenesis various endocrine cell types. For this tabular data collection, the following were considered: steroidogenic acute regulatory protein (StAR), side chain cleavage (P450scc), 3 beta-hydroxysteroid dehydrogenase, 17-alpha-hydroxylase/17,20-lyase (P450c17), 17-beta-hydroxysteroid-dehydrogenase, aromatase complex, 5-alpha-reductase, P450c21, DHEAS sulfatase, DHEA sulfotransferase. This collection summarizes current information on how mentioned cytokines influence particular steps.
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