Epidemiologic features of Kawasaki disease in acute stages in Taiwan, 1997–2010: Effect of different case definitions in claims data analysis

摘要: Abstract Background Kawasaki disease is the leading cause of pediatric acquired cardiac in many industrialized countries. The aim this study was to estimate incidence acute stages Taiwan, by linking diagnosis code medication and comparing differences epidemiological features with those previous reports that used alone. Methods We searched National Health Insurance Research Database from 1997 2010. For International Classification Diseases, Ninth Revision (ICD-9) set, all inpatients a main (ICD-9, 446.1) were retrieved. ICD-9 + intravenous immunoglobulin (IVIG) defined as requiring IVIG. epidemiologic calculated compared both methods. Results rates for children under 5 years ranged 21.5 68.5 per 100,000 person-years (average 49.1) ICD-9 + IVIG set 48.5 82.8 74.9) ICD-9 set. Significant discrepancy peak season estimation occurred summer. 5-year recurrence rate 1.1% 4.5% coronary complication around 7.24% (ICD-9 + IVIG) 6.48% (ICD-9). Conclusion Discrepancies when different case definitions claims data analysis. Previous might have overestimated incidence, rate, older children. new method slightly underestimate them. true lie between.