Identification of microbial polynucleotides expressed during infection of a host

作者: Jeffrey Daniel Hillman

DOI:

关键词:

摘要: The invention provides methods useful for identifying polynucleotides expressed in vivo by a microbe during infection of host. Antibodies against antigens that are the and vitro adsorbed with cells or cellular extracts have been grown vitro. Unadsorbed antibodies isolated probed phage display library microbe's DNA RNA. A polynucleotide is identified.

参考文章(28)
D Haubek, K Poulsen, J Westergaard, G Dahlèn, M Kilian, Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin. Journal of Clinical Microbiology. ,vol. 34, pp. 1576- 1578 ,(1996) , 10.1128/JCM.34.6.1576-1578.1996
J Slots, Selective medium for isolation of Actinobacillus actinomycetemcomitans Journal of Clinical Microbiology. ,vol. 15, pp. 606- 609 ,(1982) , 10.1128/JCM.15.4.606-609.1982
C Li, J K Ichikawa, J J Ravetto, H C Kuo, J C Fu, S Clarke, A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome. Journal of Bacteriology. ,vol. 176, pp. 6015- 6022 ,(1994) , 10.1128/JB.176.19.6015-6022.1994
Robert D Fleischmann, Mark D Adams, Owen White, Rebecca A Clayton, Ewen F Kirkness, Anthony R Kerlavage, Carol J Bult, Jean-Francois Tomb, Brian A Dougherty, Joseph M Merrick, Keith McKenney, Granger Sutton, Will FitzHugh, Chris Fields, Jeannine D Gocayne, John Scott, Robert Shirley, Li-lng Liu, Anna Glodek, Jenny M Kelley, Janice F Weidman, Cheryl A Phillips, Tracy Spriggs, Eva Hedblom, Matthew D Cotton, Teresa R Utterback, Michael C Hanna, David T Nguyen, Deborah M Saudek, Rhonda C Brandon, Leah D Fine, Janice L Fritchman, Joyce L Fuhrmann, NSM Geoghagen, Cheryl L Gnehm, Lisa A McDonald, Keith V Small, Claire M Fraser, Hamilton O Smith, J Craig Venter, Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. ,vol. 269, pp. 496- 512 ,(1995) , 10.1126/SCIENCE.7542800
Denis F. Kinane, John Mooney, Jeffrey L. Ebersole, Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease Periodontology 2000. ,vol. 20, pp. 289- 340 ,(1999) , 10.1111/J.1600-0757.1999.TB00164.X
Chi-Cheng Tsai, William P. McArtkur, Pierre C. Baehni, Cyril Evian, Robert J. Genco, Norton S. Taichman, Serum neutralizing activity against Actinobacillus actinomycetemcomitans leukotoxin in juvenile periodontitis. Journal of Clinical Periodontology. ,vol. 8, pp. 338- 348 ,(1981) , 10.1111/J.1600-051X.1981.TB02043.X
Harry Smith, What happens to bacterial pathogens in vivo? Trends in Microbiology. ,vol. 6, pp. 239- 243 ,(1998) , 10.1016/S0966-842X(98)01250-5
Yi-Chyi Lai, Hwei-Ling Peng, Hwan-You Chang, Identification of Genes Induced In Vivo duringKlebsiella pneumoniae CG43 Infection Infection and Immunity. ,vol. 69, pp. 7140- 7145 ,(2001) , 10.1128/IAI.69.11.7140-7145.2001