2-oxothiatole compounds having activity as CPLA2 inhibitors for the treatment of inflammatory disorders and hyperproliferative disorders

摘要: A compound of formula (I′) wherein R 6 is H, C 1-6 alkyl, —(CH 2 ) p COOH, COOC CONH , CONHC CON(C alkyl) 7 as defined for ; or and taken together with the atoms joining them can form a 6-membered aromatic non aromatic, saturated unsaturated, carbocyclic heteroatom containing (e.g. O, N S containing) ring optionally substituted by up to 4 groups 8 each oxo; 10 Ar 6-14 aryl group, group may be (preferably in mew para position relative O) one more 9 groups; halo, OH, CN, nitro, NH NHC N(C haloC 6-10 7-12 arylalkyl, 1-10 alkyl 2-10 -mono multiply unsaturated alkenyl OC SC —OC alkyl-O—C —C OAr O(CH q SAr S(CH phenyl, trihalomethyl, -alkoxy, alkyl; 1 3, preferably 1; 0 3; salt, ester, solvate, N-oxide, prodrug thereof.