Age-related differences in plasma and intracellular tenofovir concentrations in HIV-1-infected children, adolescents and adults
作者： Gautam Baheti , Jennifer R. King , Edward P. Acosta , Courtney V. Fletcher
DOI: 10.1097/QAD.0B013E32835A9A2D
关键词:
摘要: Tenofovir disoproxil fumarate (TDF), anucleotide analogue and prodrug of tenofovir (TFV), is widely used in combination with other antiretrovirals for treatment human immunodeficiency virus type 1 (HIV-1) infection. Intracellular phosphorylation TFV to TFV-diphosphate (TFV-DP) necessary inhibition viral reverse transcriptase. Our previous work has elucidateda relationship between plasma concentrations formation intracellular TFV-DP adults [1]. We showed could be described as a function an indirect, stimulation response, maximum effect (Emax) model. The estimated elimination half-life was 87 hours, consistent vitro data. Pediatric pharmacokinetic data are limited; information on children even more so. International Maternal Pediatric Adolescent AIDS Clinical Trial Group (IMPAACT) study P1058 evaluated the steady-state pharmacokinetics HIV-infected pediatric patients stable antiretroviral therapy; have been previously published [2]. objective present describe these investigate age related differences.
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