Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy-the national cancer centre singapore experience.

摘要: Purpose The aim of this study was to determine the efficacy and acute toxicity our early experience with treating nasopharyngeal carcinoma (NPC) patients intensity-modulated radiotherapy (IMRT). Methods materials A review conducted on case records 195 histologically proven, nonmetastatic NPC treated IMRT between 2002 2005. MRI head neck fused CT simulation images. All plans had target volumes at three dose levels, a prescribed 70 Gy gross disease, in 2.0–2.12 Gy/fraction over 33–35 fractions. Cisplatin-based chemotherapy offered Stage III/IV patients. Results Median patient age 52 years, 69% were male. follow-up 36.5 months. One hundred twenty-three disease (63%); 50 (26%) T4 disease. eighty-eight (96%) complete response; 7 (4%) partial response. Of responders, 10 (5.3%) local recurrence, giving 3-year recurrence-free survival estimate 93.1% disease-free 82.1%. Fifty-one least one Grade 3 toxicity. Conclusions from series are comparable those reported by other centers. Acute is common. Local failure or persistent especially bulky issues that must be addressed future trials.